In the subgroup of ICS-positive PTs (Figures 1A-D), there were only female patients (p = 0.013), more frequent rare histological variants (p = 0.047, the Warthin-like and tall cell variants), more frequent pronounced oncocytic changes (in > 50% TECs, p = 0.013), higher Ki-67 LI (p = 0.003), and higher frequencies of p16-positivity (in > 50% TECs, p = 0.030) and of chronic thyroiditis (p = 4.41E-04). This evidence concerns the gene CDKN2A and Hashimoto thyroiditis.