Using the IVW technique in MR analysis, we found significant relationships of 24 genetically predicted risk factors, such as “Apoliprotein A” (OR= 0.83; 95% CI: 0.76, 0.91), “Forced expiratory volume in 1-second (FEV1)” (OR=0.76; 95% CI: 0.63, 0.92), “Insulin-like growth factor 1 (IGF-1)” (OR=1.16; 95% CI: 1.08, 1.26) and “Usual walking pace” (OR=0.19; 95% CI: 0.09, 0.39), with GDM (Figures 1, 2, Supplementary Table 3). This evidence concerns the gene IGF1 and gestational diabetes.