In unilateral UUO and folic acid renal fibrosis models, retinoic acid-inducible gene-I (RIG-I) functions as a promoter of NF-κB (nuclear factor-kappa B) signaling, leading to the activation of NF-κB signaling and facilitating the production and secretion of IL-1β and IL-6 in PTECs. This evidence concerns the gene IL1B and renal fibrosis.