• High expression of GPRC5A is associated with increased bone-metastatic lesions as well as a lower survival rate in patients with prostate cancer• Reducing cell proliferation via induction of cell cycle arrest at the G2/M phase in GPRC5A KO PC3 cells• Repressing bone metastasis in xenograft mice models. The gene discussed is GPRC5A; the disease is Familial prostate cancer.