SREBF1 and neoplasm: • SREBP1 is an abnormal lipid metabolism regulator and could be involved in the metastasis and progression of tumor cells in bone metastatic prostate cancer• Combining the siRNA interferes with SREBP1 with docetaxel in a nano delivery system (PB@LC/D/siR) could inhibit tumor cells proliferation, migration, and invasion with high safety, deep tumor penetration, and decent bone protection at the tumor site• Reducing the expression of SREBP1 and stearoyl-CoA desaturase-1 (SCD1)