• Enhancing their ability to metastasize by reducing the expression ALKBH5• The decreased levels of ALKBH5 worsen the pro-metastatic characteristics of HCC by modulating gene expression through both N6-methyladenosine-dependent and -independent mechanisms• In mouse models treated with BM-EVs, liposomes loaded with antagomir-miR-3190 and targeting HCC cells successfully suppress the progression of HCC. The gene discussed is ALKBH5; the disease is hepatocellular carcinoma.