• Engineered macrophages carrying nanomedicine containing photosensitizer and oxaliplatin prodrug• Chemo/immunotherapy• Inducing the polarization of macrophages to the M1 phenotype• Eliminate primary tumor cells through chemo-photodynamic therapy and induction of immunogenic cell death• The combination of anti-PD-L1 with Oxa(IV)@ZnPc@M lead to the elimination of bone-metastatic tumor cells• Promoting tumor-specific immune response• Prolonging overall survival with minimum systemic toxicity. The gene discussed is CD274; the disease is neoplasm.