Although routine evaluation of solitary thyroid nodules with serum calcitonin level is not recommended by any of the society guidelines due to lack of uniform data, lack of cost-effectiveness, and resource constraints (21–23), serum calcitonin in the background of nodular thyroid diseases allows the preoperative diagnosis of unsuspected sporadic MTC as seen in this study. The gene discussed is CALCA; the disease is thyroid nodule.