Triptorelin, cetrorelix (pan GnRHR antagonist), and GnRH2 exerted anti-proliferative effects on endometrial cancer cells (Ishikawa, HEC-1A, and HEC-1B) that produce GnRHR1 and GnRHR2 transcripts (18). This evidence concerns the gene GNRHR2 and endometrial cancer.