Consistent with this, GnRH2 expression is elevated in prostate cancer cells (e.g., LNCaP cells) that produce androgen receptors (ARs) compared to those lacking ARs (e.g., PC3 cells (55)) and AR inhibition blocked androgen-mediated increases in GnRH2 expression in LNCaP cells. Here, GNRH2 is linked to Familial prostate cancer.