IGFLR1 and osteoporosis: While, IGF-LR1 levels displayed a negative association with osteoporosis, according to the MR-Egger method (OR = 0.886, 95% CI = 0.795–0.987, P = 0.036), while CYR61 was linked to an increased risk of osteoporosis based on both the weighted median and IVW methods (OR = 1.154, 95% CI = 1.009–1.319, P = 0.037, and OR = 1.115, 95% CI = 1.022–1.215, P = 0.014, respectively).