Maity et al. (2022) reported that the expression levels of mitophagy-related molecules PINK1 and Parkin in DPSC were increased, and mitophagy was induced to promote osteoblast differentiation. It has also been reported that epigallocatechin-3-gallate (EGCG) is a rich polyphenol in green tea, which can significantly reduce the expression of mitochondrial autophagy related PINK1 and Parkin. inhibit osteoclast differentiation, and regulae the progression of osteoporosis (Sarkar et al., 2022). This evidence concerns the gene PRKN and osteoporosis.