ESR1 and osteoporosis: In addition, NELFB can inhibit the transcription of estrogen receptor (ER) receptor gene, interfere with its binding to estrogen, inhibit the expression of osteoprotegerin (OPG), and promote the role of nuclear factor (NF)-κB ligand (RANKL), thereby promoting osteoclast formation and bone resorption activity, which is closely related to the pathogenesis of osteoporosis (Cheng CH.