For example, KDM4B inhibits the formation of H3K9me3 (heterochromatin) lesions to reduce MSC self-renewal and affect osteoporosis (Deng et al., 2021), whereas sIRT3 inhibits the generation of heterochromatin through the vulcanization of hydrogen sulfide, thereby inhibiting the senescence of BMSC and providing a new target for the treatment of osteoporosis (Liu et al., 2023). The gene discussed is SIRT3; the disease is osteoporosis.