The network based on hub genes showed that 3 TFs (TRIM22, CEBPG, and CEBPZ), 4 miRNAs (hsa-miR-132-3p, hsa-miR-182-5p, hsa-miR-212-3p, and hsa-miR-324-5p), and 4 drugs were involved in osteoporosis. The gene discussed is TRIM22; the disease is osteoporosis.