In this study, although the interaction analysis of the 7 main phenolic compounds in RLE and obesity through network pharmacology had predicted 12 potential targets, based on experimental results and literature reports, it was speculated that IL-6, TNF, AKT1, and PPAR may be key targets for RLE polyphenols in regulating obesity. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.