Whole exome sequencing of the parents and their monozygotic triplets, part of a Qatari cohort recruited for an autism genetics study, identified two genetic variants of potential interest: a missense mutation in VPS13B, c.8516G>A 9 (p.Arg2839Gln); and a splice site loss variant in NAPB, c.354+2T>G. The gene discussed is VPS13B; the disease is autism.