There was a significant association (p < 0.001) between cognitive impairments and decreased level of synapsin-I (r = 0.649; Figure 7A), synaptophysin (r = 0.642; Figure 7B), GAP-43 (r = 0.687; Figure 7C), SNAP-25 (r = 0.379; Figure 7D), drebrin (r = 0.654; Figure 8A), SAP-97 (r = 0.697; Figure 8B), and PSD-95 (r = 0.605; Figure 8C) in hippocampal synaptosomes following STZ injection. The gene discussed is GAP43; the disease is Cognitive impairment.