DBN1 and Cognitive impairment: Displacement or lack of drebrin at its actin-biding site (Minamide et al., 2000; Zhao et al., 2006) and postsynaptic membranes (Ma et al., 2008) are markedly associated with cognitive impairments in AD (in clinical and preclinical samples) (Zhao et al., 2006; Arsenault et al., 2013).