CLDN5 and Sepsis: reported that baseline expression levels of occludin, claudin-5, and VE-cadherin markedly differed between kidney and lung, with claudin-5 and VE-cadherin being highly expressed in the lung, and occludin being highly expressed in the kidney during sepsis in mice and humans, indicating an organ-specific molecular manifestation of ECs (Aslan et al., 2017).