Ghrelin in patients with non-alcoholic steatohepatitis (Yalniz et al., 2006), alcoholic hepatitis (Moreno et al., 2010), chronic hepatitis C (Kawaguchi et al., 2013; Hamdy et al., 2018) or chronic hepatitis B (Zhang X. et al., 2015) was significantly lower than that in healthy patients, after progressing to cirrhosis, it continued to decrease significantly, and it was significantly lower in patients with decompensated liver cirrhosis than in patients with compensated liver cirrhosis (Breidert et al., 2004; Kalaitzakis et al., 2007; Diz-Lois et al., 2009). The gene discussed is GHRL; the disease is cirrhosis of liver.