GHRL and Hepatic fibrosis: Studies had also pointed out that high expression of Ghrelin could increase the expression of bcl-2 and eNOS in rats with liver fibrosis, and significantly reduce the levels of serum liver enzymes, TNF-α and liver tissue collagen, suggesting that Ghrelin could resist liver cell apoptosis and mediate NO release to fight liver fibrosis (Kabil et al., 2014).