Studies had also pointed out that high expression of Ghrelin could increase the expression of bcl-2 and eNOS in rats with liver fibrosis, and significantly reduce the levels of serum liver enzymes, TNF-α and liver tissue collagen, suggesting that Ghrelin could resist liver cell apoptosis and mediate NO release to fight liver fibrosis (Kabil et al., 2014). This evidence concerns the gene TNF and Hepatic fibrosis.