IGF1 and serum lipopolysaccharide activity: In addition, IGF-I was found to directly inactivate HSCs, improve portal pressure, bacterial translocation, endotoxemia, and collagen levels, reverse hepatic insulin resistance to protect liver cells from damage, stimulate the secretion of cell growth factors, and lead to liver regeneration (Sanz et al., 2005; Sobrevals et al., 2010; Chishima et al., 2017), but the serum IGF-I level was significantly reduced in cirrhotic patients (Blaas et al., 2010; Abdel-Wahab et al., 2015).