TIMP2 and acute kidney injury: The kinetics of urinary biomarkers associated with AKI [tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein (IGFBP7)], were evaluated following renal insults such as surgery or drug exposure.33 This study concluded that exposure to multiple nephrotoxins during critical illness is common and cumulative renal insults increase the risk of AKI.