The expression of focal adhesion-related genes was positively correlated with prognosis in LUSC patients, and 10 focal adhesion-related genes were determined using the prognostic model for LUSC patients: ITGA3, VAV2, FLNC, FLT4, HGF, MYL2, ITGB1, PDGFRA, CCND2, and PPP1CB. Integrin alpha-3 (ITGA3) regulates cancer cell migration and invasion in head and neck cancer (17). This evidence concerns the gene VAV2 and head and neck cancer.