Severe loss of pyramidal cells in the hippocampus. In several affected areas, prominent glial-fibrillar astrocytosis is associated with massive macrophage/microglia (CD68+) activation and diffusely dispersed infiltrates of cytotoxic T lymphocytes. Negative SV-40 stain ruled out multifocal leukoencephalopathy. CAR-T cell DNA in the most affected areas suggests that patient died of severe CAR-T-cell-triggered autoimmune encephalitis. Here, CD68 is linked to autoimmune encephalitis.