As showed in Figure 1B, 8 specific SAGs including HGF, IL10, CD55, MMP9, ETS2, GMFG, IGFBP7, and IL18 were upregulated in the peripheral blood of sepsis, whereas 5 other SAGs (RPS6KA5, CCL5, IL32, CCL4, and CXCL8) were downregulated. The gene discussed is CXCL8; the disease is Sepsis.