Therefore, individuals with lowered or impaired levels of OSA1 due to expressive quantitative trait loci (eQTL) variants could demonstrate an inflammatory response to COVID-19 as well as AD-associated pathology, which can trigger a ‘cytokine storm’ and potentially cause cell death and damage to neighbouring cells such as of the alveoli and neurons (Magusali et al., 2021). This evidence concerns the gene ARID1A and Alzheimer disease.