Our study revealed that LMNA splicing mutations resulted in LMNA-related DCM in 58.2% of cases and AVB in 62.7% of cases, which is markedly higher than the incidence rates of 6.2% and 32% reported for LMNA missense mutations in another study (Hasselberg et al., 2018). This evidence concerns the gene LMNA and familial dilated cardiomyopathy.