BCL2 and central nervous system cancer: TMZ is a potent inducer of senescence (Hirose et al., 2001), and pre-clinical studies of glioma cells have identified other inducers to be nutlin-3a (Villalonga-Planells et al., 2011) and resveratrol (Filippi-Chiela et al., 2013), among others, and senolytics to include BH3 mimetics that target pro-survival BCL2 family members, which are regulators of apoptosis (Schwarzenbach et al., 2021).