HIVEP2-DT and osteoarthritis: Adenovirus-mediated expression of PILA Long non-coding RNA PILA stimulated NF-κB signaling in OA, induing spontaneous cartilage degradation by regulating MMP3, MMP13, and ADAMTS4 in knee joints of DMM-induced mice, thus leading to the degradation of articular cartilage and exacerbating inflammation in osteoarthritis (Tang et al., 2022b).