SPP1 and age-related macular degeneration: The upregulated pathways in SPP1-high AMD macular neuroretina included angiogenesis-related pathways (blood vessel development and angiogenesis), glia-activation pathways (gliogenesis, glial cell proliferation, glial cell differentiation, and glial cell development), Inflammatory response pathway, and Endothelial cell proliferation pathway (Figure 6C).