IL18 and age-related macular degeneration: Pathway enrichment analysis was then performed and the mainly upregulated pathways in microglia of AMD neuroretina included phagocytosis-related pathways (Phagosome, Microglia phagocytosis pathway, Synapse pruning, Regulation of cell killing, and Positive regulation of neuron death), complete activation-associated pathways (C1q complex and Complete activation), inflammation-related pathways (IL-18 signaling pathway and Regulation of inflammatory response) and Regulation of chemotaxis pathway (Figure 5B).