Plastin 3 (PLS3), an actin-bundling protein which interacts with F-actin and calcium, was shown to rescue motor neuron pathology, NMJ structure and function when overexpressed in a variety of SMA animal models (Oprea et al., 2008; Dimitriadi et al., 2010; Hosseinibarkooie et al., 2017). Here, PLS3 is linked to proximal spinal muscular atrophy.