(389) evaluated that suppression of hyaluronan (HA) synthesis protects against CNS autoimmunity and augments CXCL12 expression within the inflamed CNS, alleviating neuroinflammation in a mice model of EAE through the administration of 4-methylumbelliferone (4MU), a widely recognized inhibitor of HA synthesis. This evidence concerns the gene CXCL12 and Autoimmunity.