Enhancing intracellular nicotinamide adenine dinucleotide (NAD+) levels, through Vitamin B3 supplementation, is found to support sirtuin-1, Cebpa, Cebpb, G-CSF and G-CFSr expression for neutrophilic differentiation and migration in CD34+ hematopoietic progenitor cells, the promyelocytic leukemia cell line HL-60, and in primary bone marrow CD34+ cells from severe congenital neutropenic patients (91). The gene discussed is CD34; the disease is acute promyelocytic leukemia.