CD4 and cancer: To investigate the underlying antitumor mechanism of FeMOF-based cancer vaccines encapsulated with dLLC autologous tumor antigens, the spleens of mice at the endpoint of antitumor experiments were collected to analyze CD4+, CD8+, CD44highCD62Lhigh in CD4+, and CD44highCD62Lhigh in CD8+ T cell populations (Figures 6, 7).