MUC1 and asthma: MUC1 has been reported to play a protective role in allergic asthma as it modulated corticoid resistance in severe asthma, MUC1 levels were downregulated in patients with severe asthma, were inversely correlated with daily doses of inhaled steroids, and MUC1-/- mice were resistant to the anti-inflammatory dexamethasone treatment in OVA model of disease (46).