In most of these ALPS-like disorders, total Treg CD4+CD25+FoxP3+ levels are lower compared to healthy controls, as well as lower CTLA-4 expression levels and an expansion of circulating follicular CD4+CXCR5+CD45RA- (cTFH) T cells and polarization towards a Th1 phenotype (CCR6-CXCR3+) (92). Here, CD4 is linked to autoimmune lymphoproliferative syndrome.