As a result, CYR61 was downregulated in most of the cancer types, such as BRCA, adrenocortical carcinoma (ACC), bladder urothelial carcinoma (BLCA), kidney chromophobe (KICH) and liver hepatocellular carcinoma (LIHC), amongst others (Figure 1A). Here, CCN1 is linked to bladder transitional cell carcinoma.