CD4 and invasive breast carcinoma: As a result, in both BRCA and ER-positive BRCA, the CYR61 expression level positively correlated with the infiltrations of some antitumor immune cell types including resting memory CD4 T cells and naive B cells, whereas negatively correlated with the infiltrations of Treg cells and M2 type macrophages that play a crucial role in immunosuppression.