SLC6A7 and neoplasm: Using two different murine tumor models, our experiments demonstrated that the i.t. administration of poly(I:C)+R848-prot-NCs showed potent antitumor efficacy and ability to prevent spontaneous lung metastasis with evidence of systemic activation of antitumor immunity; the intravenous administration of poly(I:C)+R848-HA-man-prot-NCs reduced the growth of orthotopic lung tumors through demonstrated reprogramming of interstitial macrophages increasing the M1/M2 ratio.