CD8A and neoplasm: This suggests firstly that myeloid cells, specifically macrophages, play a role in ICB resistance and that combined CpG-STAT3ASO and anti-PD-1-mediated reprogramming of macrophages promotes antitumor immunity resulting in increased tumor growth control and a concurrent increase in CD8+ T-cell infiltration and CD8/Treg ratios in combination-treated tumors.