We confirmed that PBMC and tumor cells released small amounts of galectin-3 (Figures 2G, H), which were significantly increased when coculturing PBMC with ovarian cancer cell lines (KI-OCp1 and 15, BG-1 and SKOV-3) in the presence of zoledronate after 72 hours (Figures 2K, M). This evidence concerns the gene FBXO2 and neoplasm.