By firstly focusing on γδ T-cell cytotoxicity, we cocultured a Vδ1 and a Vδ2 T-cell line established from a healthy donor together with ovarian tumor cells (KI-OCp012, OVCAR-3, SKOV-3) and PDAC PancTuI cells in the absence or presence of bispecific T-Cell Engagers (bsTCE) targeting Vδ1 and Vδ2 T cells and HER-2 expressing tumor cells (Figure 3). Here, ERBB2 is linked to neoplasm.