ISG15 and infection: For the primate responses shared with ERBs, some DEGs showed mainly sustained or stronger activation (e.g., CD274, IFI6, ISG15, MX1, OAS1) when transitioning from mid- to late-stage infection, while other DEGs showed mainly reduced activation (e.g., IFIT1, PML, TAP1), but for most of these shared primate DEGs, the level of activation between disease stages was study-dependent.