ISG15 and viral infectious disease: Peripheral responses shared between filovirus-infected ERBs and primates were typical of mammalian viral infections and encompassed almost all the DEGs we identified for ERBs, showing strikingly similar induction of mainly canonical antiviral ISGs (e.g., ISG15, MX1, OAS1/3, IFITs, STAT1, FOS, etc.), along with anti-inflammatory/regulatory genes, predicted to be driven by monocyte-derived cells (macrophages and DCs) and T cells.