IFN-γ significantly increased B cell lymphoma 6 (Bcl6), PR domain containing protein (PRDM1), and paired box homeotic gene 5 (PAX5) levels in B cells from IgG-4-DS patients and immortalized B cell lines, while IL-4 could increase the expression of X-Box Binding Protein 1 (XBP1) (95). This evidence concerns the gene XBP1 and Dravet syndrome.