The main objective of this study is to identify the expression of BCAS3 gene in HNSCC. We analyzed the BCAS3 expression using The Cancer Genome Atlas-Head-Neck Squamous Cell Carcinoma (TCGA-HNSC) dataset and OSCC through the University of Alabama at Birmingham CANcer data analysis portal (UALCAN) database and RT-qPCR. This evidence concerns the gene BCAS3 and head and neck squamous cell carcinoma.