NPPB and myocardial infarction: In comparison, in adult mice Nfatc2 does not appear to be significantly upregulated by cardiomyocytes following myocardial infarction (Supplementary Figures S2B,C), however there is a significant increase in the cardiomyocyte expression of Nppb in infarcted mouse hearts (Supplementary Figures S3B,C).