MHRT executes its function by antagonizing Brg1, part of the pathological stress-activated Brg1-Hdac-Parp chromatin repressor complex in TAC mice (27-gauge needle) (80) and by promoting SUMOylation of SIRT1, leading to the activation of the PGC1-α/PPAR-α pathway in Ang-II treated neonatal rat cardiomyocytes as a model for hypertrophy (160). This evidence concerns the gene SMARCA4 and persistent truncus arteriosus.