IGHE and asthma: Our understanding of T2-high asthma has matured over the last two decades, with key findings for biomarkers representing this phenotype: bronchoalveolar lavage (BAL) fluid, blood and sputum eosinophilia, high levels of serum immunoglobulin-E (IgE), and high fractional exhaled nitric oxide (FeNO) measurements (Dunican and Fahy, 2015a; Fahy, 2015a).