NFE2L2 and type 2 diabetes mellitus: By promoting the expression of Nrf2, NQO-1, and HO-1 and suppressing the expression of Keap1 mRNA in the hearts of diabetic mice, Huo et al.'s research in a mouse model of type 2 diabetes revealed that SCU plays an essential part in reducing oxidative damage and the severity of type 2 diabetes-induced cardiac complications (Huo et al., 2021).