SCU can intervene in cardiovascular system diseases through multiple signal pathways, including the TGF-β1/MAPK signal pathway, PI3K/AKT/mTOR signal pathway, Nrf2/Keap/ARE signal pathway, NOTCH signal pathway, etc. Among them, PI3K/AKT/mTOR, NOTCH, cGAS-STING, and CaMKII signal pathways have been the hot research pathways in the cardiovascular field in the last 5 years. Here, NFE2L2 is linked to cardiovascular disorder.