TGFB1 and Myocardial fibrosis: In a different series of Ang II-induced myocardial fibrosis experiments in rats, it was discovered that SCU not only prevented Ang II-induced CFs’ growth and production of collagen as well as downregulated their expression of FN1 and TGF-β1, but also prevented the phosphorylation of both ERK1/2 and p38-MAPK.