HMOX1 and hyperlipidemia: Fan et al. (2017) in an experiment to induce hyperlipidaemia in rats, found that SCU attenuated oxidative damage by increasing the expression of Nrf2, HO-1, PI3K, and AKT proteins, thereby improving serum and liver lipid metabolism levels. This suggests that through the Nrf2/Keap/ARE signal pathway, SCU can contribute to improved lipid metabolism and anti-hyperlipidemia (Figure 3).