TLR4 and diabetes mellitus: In addition, Huo and others found that SCU inhibited the increase of cardiac inflammatory markers in diabetic mice, such as TLR4, MyD88, NF-κB, and IL-6, through the TLR4/MyD88/NF-κB signal pathway, as well as inhibited the increase in the protein distribution of NF-κB and TNF-α and the decrease in the protein distribution of IKKβ in the diabetic cardiac immunohistochemical sections in their experiments on the type 2 diabetes mellitus model (Huo et al., 2021).