Over-expression of the P2X7 receptor is found within the seizure focus in experimental and human epilepsy (Rappold et al., 2006; Jimenez-Pacheco et al., 2016; Wei et al., 2016), an observation recently extended by the use of P2X7 receptor radiotracers (Mikkelsen et al., 2023; Morgan et al., 2023). This evidence concerns the gene P2RX7 and epilepsy.