CXCL8 and neoplasm: Approaches include targeting inhibitory cytokines like IL-8 to potentiate immune checkpoint blockade (Cancer Cell), exploiting IFNγ signaling pathways to improve CAR T cell efficacy (Nature), using an engineered cytokine nanocarrier for deliver and tumor vessel normalization (Nature Nanotechnology), and modulating abnormal tryptophan metabolism via cytokines to overcome immunosuppression (Nature Cancer).