Approaches include targeting inhibitory cytokines like IL-8 to potentiate immune checkpoint blockade (Cancer Cell), exploiting IFNγ signaling pathways to improve CAR T cell efficacy (Nature), using an engineered cytokine nanocarrier for deliver and tumor vessel normalization (Nature Nanotechnology), and modulating abnormal tryptophan metabolism via cytokines to overcome immunosuppression (Nature Cancer). This evidence concerns the gene IFNG and cancer.