Salidroside has the potential to activate the Akt/GSK-3β signaling pathway in the kidney of rats with DN, indicating that increased levels of phosphorylated Akt and GSK-3β can suppress the production of inflammatory factors, mitigate oxidative stress and inflammatory response, enhance cellular glucose uptake, and alleviate apoptosis, thereby ameliorating renal tissue injury. This evidence concerns the gene GSK3B and liver dysplastic nodule.