Previous studies have emphasized the significant anti-inflammatory effects of salidroside in sepsis, notably, this study emphasizes its regulatory role within septic AKI’s complex immune network inflammation by reducing plasma and kidney levels of TNF-α, IL-1β, and IL-17A, which are pivotal cytokines involved in the pathogenesis of sepsis (Liu et al., 2015; Lan et al., 2017). Here, TNF is linked to Sepsis.