The main mechanism is that salidroside induced significant G1 cell cycle arrest and apoptosis in A498 and 786-0 cells, and reduced the phosphorylation level of JAK2 and STAT3, which are key proteins in the JAK2/STAT3 signaling pathway, and thus exhibited potent anticancer properties in renal cell carcinomas (Lv et al., 2016). Here, STAT3 is linked to hereditary clear cell renal cell carcinoma.