HMOX1 and major depressive disorder: Dang et al. investigated the effects of EDA and showed its ability to reduce oxidative stress and ferroptosis through the Silent information regulatory factor 2 homologous protein 1 (Sirt1)/Nrf2/Heme oxygenase-1 (HO-1)/Gpx4 pathway, thereby inhibiting the development of depression (DANG et al., 2022).