APOE and atherosclerosis: However, the results of the present study show that one of the most popular senolytic drugs, ABT-263, has multiple detrimental effects on Apoe–/– mice with advanced atherosclerosis; these effects include causing a reduced probability of survival by 50%–60% that may be due to a reduced α-SMA+ fibrous cap thickness and a 90% reduction in SMC within the lesions.