APOE and Wilson disease: First, to better match clinical paradigms of treating elderly patients with advanced disease, we did a late-stage intervention study (35) involving initiation of ABT-263 treatment in Apoe–/– mice after 18 weeks of WD (TD.88137; 42% calories from fat) feeding so that they already have highly advanced BCA lesions closely resembling advanced human lesions both morphologically (2) and in cellular composition of lesions, as determined by scRNA-Seq analysis (15).