However, there is a need for further studies in mouse models that, unlike Apoe–/– and Ldlr–/– mice, develop coronary lesions that undergo spontaneous plaque rupture and MI in mice that are truly aged (i.e., > 1.5 years) and in mice that have modest increases in plasma cholesterol and lipid levels similar to high CAD risk patients. Here, APOE is linked to coronary artery disorder.