In conclusion, ABT-263 treatment of WD-fed Apoe–/– mice with advanced atherosclerosis and persistent hyperlipidemia had multiple unexpected detrimental effects, including the induction of reduced Myh11-eYFP+ SMC–derived cells within lesions and the fibrous cap and decreased α-SMA+ fibrous cap thickness. The gene discussed is MYH11; the disease is hyperlipidemia.