Profiling of glucagon secretion from islets or dispersed islet cells (29) showed that WCDD301 reduced glucagon secretion from islets (Figure 2G) and dispersed islet cells (Figure 2H) from donors with long-standing T1D with no effect on the minimal residual insulin secretion from islets (Figure 2I) or dispersed islet cells (Figure 2J). The gene discussed is GCG; the disease is type 1 diabetes mellitus.