AGT and endothelial dysfunction: Moreover, angiotensin II and high salt promote endothelial dysfunction,67, 68 which consequently increases the expression of proinflammatory molecules and MMPs69, 70, 71, 72 that are known to contribute to IA pathophysiology5, 55, 58; therefore, while using an animal model using angiotensin II or deoxycorticosterone to study endothelial dysfunction in IAs formation, the direct effect of angiotensin II and high salt on endothelial cells should be considered.