In the recent ten years, many CDK8 inhibitors have been reported to exhibited good anti-tumour activity, such as cortistainA10, AU1-10011, MK-25612, SEL120-34A7, CCT25154513, CCT25159114, MSC253081815, BI-134716,17, etc. It has been reported compound SEL120-34A (Figure 1) as the potent CDK8 inhibitor could inhibit the phosphorylation of STAT1 S727 and STAT5 S726 in AML cells.7 The gene discussed is STAT1; the disease is acute myeloid leukemia.