In addition, in the C57Bl/6 mice diet-induced obesity model, mesoporous silica particles supplemented in food successfully reduced adipose tissue formation (6.5 ± 0.5 vs. 9.4 ± 1.2 g), leptin levels (32.8 ± 7.4 vs. 16.9 ± 1.9 ng/mL), and 33% reduction of food efficiency in comparison to mice in the control group [32]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.