Hypoxia serves as a key driving factor for angiogenesis [46], and TAMs can sense tumor hypoxia and produce various angiogenic factors, including hypoxia-inducible factors (HIFs) [46], TGF-α, TGF-β, [47], vascular endothelial growth factor (VEGF) [48,49], and matrix metalloproteinases [55,56]. This evidence concerns the gene TGFB1 and neoplasm.