The main cytokines affected in CLL patients are interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 9 (IL-9), and interleukin 10 (IL-10) [40]. This evidence concerns the gene CXCL8 and B-cell chronic lymphocytic leukemia.